Sex Differences in the Associations among Insulin Resistance Indexes with Metabolic Syndrome: A Large Cross‐Sectional Study

Abstract

The IR index levels are higher in male than female patients. In IR indexes, TyG has the highest AUC in male patients and TyG-WHtR in female patients. The combination of IR indexes improved diagnostic efficiency compared with a single parameter. Moreover, the IR indexes are independently associated with MetS except for TyG-WHtR and TG/HDL-C in female patients. Our findings indicate that the multi-index association of IR indexes may play a potential role in MetS diagnosis, and understanding the sex differences in risk factors for MetS may help doctors properly implement more individualized prevention strategies.