Discovery of a potent, Highly selective, and In vivo anti-inflammatory Efficacious, P2Y6R antagonist with a novel quinoline-pyrazole scaffold

Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors

Liaman K. Mamedova, Bhalchandra V. Joshi, Zhan‐Guo Gao et al. · Biochemical Pharmacology · 2004 · 166 citations

Medicine, Medicinal Chemistry, Pharmacology +8

P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport

Michael Köttgen, Thomas Löffler, Christoph A. Jacobi et al. · Journal of Clinical Investigation · 2003 · 68 citations · Full text

Life Sciences, Pharmacology, Physiology +17

Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury

Zhiguo Liu, Lingfeng Chen, Pengtian Yu et al. · Journal of Medicinal Chemistry · 2019 · 62 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Acute Lung Injury and the NLRP3 Inflammasome

Wanjun Gu, Qi Zeng, Xin Wang et al. · Journal of Inflammation Research · 2024 · 49 citations · Full text

Veterinary Medicine, Immunology, Pathobiology +17

Sulfonamides as Selective Na_V1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

Matthew M. Weiss, Thomas A. Dineen, Isaac E. Marx et al. · Journal of Medicinal Chemistry · 2017 · 49 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14