Acta Obstetricia Et Gynecologica Scandinavica · 1981 · 25 citations · 12 references
MedicineObstetricsPharmacotherapyClinical PharmacologyMaternal-fetal MedicineReproductive MedicineAugmentation Of LaborLabor PhysiologyPremature Rupture Of MembranesUterotonic TherapyComparative Effectiveness Of UterotonicsIntravenous OxytocinLabor DurationMaternal OxytocinOxytocin UseProstaglandin PhysiologySpontaneous Rupture Of Membranes
Prostaglandin E 2 ‐tablets were compared to in‐ravenous oxytocin for the stimulation of labor in 201 patients at or near term, with premature spontaneous rupture of the membranes without labor activity for 6 hours after the escape of fluid. The patients were randomly allocated; 99 were treated with PGE 2 ‐tablets (0.5–1.5 mg/hour) and 102 with intravenous oxytocin (7.5–45 mIU/min). The treatment was ineffective in the PGE 2 group in 3 cases; these were treated successfully with intravenous oxytocin. In the oxytocin group, 3 patients were delivered by cesarean section for reasons not associated with the drug. A significant difference was found in the stimulation‐delivery time, in favor of intravenous oxytocin. Although PGE 2 tablets are a safe and convenient alternative to intravenous oxytocin, the investigation showed that intravenous oxytocin is preferable in cases of premature rupture of the membranes with more than 6 hours without labor activity.
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