The plant extract PNS mitigates atherosclerosis via promoting Nrf2‐mediated inhibition of ferroptosis through reducing USP2‐mediated Keap1 deubiquitination

Abstract

PNS reduced USP2-mediated Keap1 de-ubiquitination and promoted Keap1 degradation, thereby activating Nrf2, improving iron metabolism and reducing lipid peroxidation, thus contributing to an anti-atherosclerotic outcome. Our study revealed the mechanism(s) underlying inhibition of ferroptosis and atherosclerosis by PNS.