Restoring Atrial T-Tubules Augments Systolic Ca Upon Recovery From Heart Failure

Abstract

We show that recovery from HF restores atrial t-tubules, and this promotes recovery of <i>I</i>_Ca-L, sarcoplasmic reticulum Ca²⁺ content, and systolic Ca²⁺. We demonstrate an important role for myotubularin in t-tubule restoration. Our findings reveal a new and viable therapeutic strategy.