Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD)

Abstract

P4 activates the c-MYC/SIRT1 axis, ameliorating CS-induced COPD and protecting both airway epithelial cells and smooth muscle cells against H₂O₂-induced oxidative damage. PGC-1α and downstream mitochondrial signaling pathways might be involved.