Photoredox/Copper Dual-Catalyzed Phosphorothiolation of Propargylic Derivatives for the Switchable Synthesis of <i>S</i>-Alkyl, <i>S</i>-Vinyl and <i>S</i>-Allenyl Phosphorothioates

Abstract

Herein, we report a photoredox/copper dual-catalyzed selective phosphorothiolation of propargylic derivatives from easily accessible [P(O)SH] compounds. This reaction provides a general, mild and versatile procedure to synthesize a variety of synthetically useful <i>S</i>-alkyl, <i>S</i>-vinyl and <i>S</i>-allenyl phosphorothioates selectively from the same set of simple starting materials.