The Antidepressant Effects of Vaporized <i>N</i> , <i>N</i> -Dimethyltryptamine: An Open-Label Pilot Trial in Treatment-Resistant Depression

Abstract

The rapid onset and sustained antidepressant effects of vaporized DMT align with the paradigm of rapid-acting antidepressants to be used in the scope of interventional psychiatry. The noninvasive route and short-acting nature of DMT offer practical advantages, potentially enhancing accessibility to psychedelic treatments.Clinical Trial Registration: Clinicaltrials.gov NCT06094907.