Lactate promotes bone healing by regulating the osteogenesis of bone marrow mesenchymal stem cells through activating Olfr1440

Metabolic regulation of gene expression by histone lactylation

Di Zhang, Zhanyun Tang, He Huang et al. · Nature · 2019 · 3.9K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis

Frédérique Végran, Romain Boidot, Carine Michiels et al. · Cancer Research · 2011 · 793 citations

Medicine, Biochemistry, Oncology +17

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

Robert Haas, Joanne Smith, Vidalba Rocher-Ros et al. · PLoS Biology · 2015 · 768 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

Jing Zhang, Jonathan Muri, Gillian Fitzgerald et al. · Cell Metabolism · 2020 · 533 citations · Full text

Life Sciences, Biomedical Sciences, Physiology +15

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

Peiwen Chen, Hao Zuo, Hu Xiong et al. · Proceedings of the National Academy of Sciences · 2017 · 505 citations · Full text

Medicine, Cancer Biology, Oncology +17