Neuroinflammation Parallels <scp>18F</scp> ‐ <scp>PI</scp> ‐2620 Positron Emission Tomography Patterns in Primary 4‐Repeat Tauopathies

Abstract

Our findings indicate that the spatial expansion of microglial activation parallels tau distribution across brain regions that are functionally connected to each other, suggesting that tau and inflammation are closely interrelated in patients with 4R tauopathies. The combination of in vivo tau and inflammatory biomarkers could therefore support the development of immunomodulatory strategies for disease-modifying treatments in these conditions. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.