Concepedia

Propofol improves sleep deprivation‐induced sleep structural and cognitive deficits via upregulating the BMAL1 expression and suppressing microglial M1 polarization

Huan Liu, Chenyi Yang, Xiaoqing Wang, Baochen Yu, Ying Han, Xinyi Wang, Zixuan Wang, Miao Zhang, Haiyun Wang

CNS Neuroscience & Therapeutics · 2024 · 18 citations · 40 references

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Abstract

Propofol reduces SD-induced cognitive impairment and circadian rhythm disruption, possibly by lowering neuronal inflammation and switching the microglia phenotype from an M1 to an M2 activated state, thus exerting neuroprotective effects.

References

40

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Christopher N. Parkhurst, Guang Yang, Ipe Ninan et al. · Cell · 2013 · 2.6K citations · Full text

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Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ

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Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice

Xiaomei Feng, Martín Valdearcos, Yosuke Uchida et al. · JCI Insight · 2017 · 349 citations · Full text

Network Features of the Mammalian Circadian Clock

Julie E. Baggs, Thomas S. Price, Luciano DiTacchio et al. · PLoS Biology · 2009 · 263 citations · Full text

, , +22

Antagonizing peroxisome proliferator‐activated receptor γ facilitates M1‐to‐M2 shift of microglia by enhancing autophagy via the <scp>LKB</scp>1–<scp>AMPK</scp> signaling pathway

Juan Ji, Tengfei Xue, Xudong Guo et al. · Aging Cell · 2018 · 211 citations · Full text