Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity

Abstract

The present data reveals that pancreatic beta cells can be protected from lipotoxicity by inhibition of FA-uptake, intracellular utilization and accumulation. FABP3 inhibition, hence, may be a useful pharmaceutical approach in obesity, metabolic syndrome, and type 2 diabetes.