Green methods for determination of paracetamol in drug samples: A comparative study

Abstract

Non-steroidal anti-inflammatory drugs like paracetamol, which have strong antibacterial and analgesic properties, are frequently employed in medicine. On the other hand, fulminant liver necrosis and other adverse reactions can result from paracetamol exposure. The development of useful analytical techniques is therefore necessary to identify and quantify paracetamol. Green determination techniques have been thoroughly studied in the last few years because of their simplicity, increased sensitivity and selectivity, and cost-effectiveness. The development of determination methods for quantification the presence of paracetamol in drugs and biological products has advanced, as this review details. The advancement in techniques for the selective detection of paracetamol during the past years was studied. In particular, the emphasis is on the inventive aspects brought about by spectrophotometry, chromatography, and automated devices. There is a lot of reviews on this topic, but no one has assessed the greenness of paracetamol determination approaches in biological samples. The two greenness scales were utilized for calculating the results. Analytical Greenness Calculator (AGREE) and Complementary Green Analytical Procedure Index (ComplexGAPI) are simple, free, and sensitive programs.