Dyskinetic crisis in GNAO1-related disorders: clinical perspectives and management strategies

Abstract

This consensus provides a foundation for understanding and managing dyskinetic crises in <i>GNAO1</i>-RD for clinicians, caregivers, and researchers. The study emphasizes the importance of targeted parental and caregiver education, which enables early recognition and intervention, thereby potentially minimizing both short- and long-term complications. Future research should concentrate on differentiating dyskinetic crises from other neurological events and investigating potential risk factors that influence their occurrence and nature. The proposed standardized framework improves clinical management, stakeholder communication, and future <i>GNAO1</i>-RD research.