Concepedia

Publication | Open Access

METTL3-Mediated N6-Methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis

DOIFull Paper Access

34

Citations

34

References

2024

Year

Yu-Cheng Tsai, Tsung‐Han Hsieh, Yuan‐Ru Liao, Ming‐Tsun Tsai, Tzu‐Ping Lin, Der‐Yen Lee, Jihwan Park, Donggun Kim, Katalin Suszták, Shang‐Feng Yang,
Journal of the American Society of Nephrology

Abstract

Our research revealed heightened METTL3-mediated m6A modification in fibrotic kidneys, particularly enriching the cGAS-STING pathway. This hypermethylation increased mRNA stability for cGAS and STING1, leading to sterile inflammation and fibrosis.

References

YearCitations

Page 1