Materials Today Bio · 2024 · 11 citations · 56 references
MedicineOrthopaedic SurgeryOrthopedic SurgeryBiomaterialsOrthopaedic BiomaterialsOrthopedic BiomaterialsBone BiomechanicsBone MechanicsImplant DesignImplant FixationImplant LooseningMetallic ImplantsOrthopedic Implant DesignPorous StructuresScrew FixationScrew Geometry DesignStress ShieldingSurgical Implants
Metallic screws are one of the most common implants in orthopedics. However, the solid design of the screw has often resulted in stress shielding and postoperative loosening, substantially impacting its long-term fixation effect after surgery. Four additive manufacturing porous structures (Fischer-Koch S, Octet, Diamond, and Double Gyroid) are now introduced into the screw to fix those issues. Upon applying the four porous structures, elastic modulus in the screw decreased about 2∼15 times to reduce the occurrence of stress shielding, and bone regeneration effect on the screw surface increased about 1∼50 times to improve bone tissue regrowing. With more bone tissue regrowing on the inner surface of porous screw, a stiffer integration between screw and bone tissue will be achieved, which improves the long-term fixation of the screw tremendously. The biofunctions of the four topologies on osteogenesis have been fully explored, which provides an advanced topology optimization scheme for the screw utilized in orthopedic fixation.
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Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Patricia Ducy, Rui Zhang, Valérie Geoffroy et al. · Cell · 1997 · 4.3K citations · Full text
Sajad Arabnejad, R. Burnett Johnston, Jenny Ann Pura et al. · Acta Biomaterialia · 2015 · 576 citations · Full text
Natural Sciences, Materials Engineering, Materials Science +17
Assessment of bone ingrowth into porous biomaterials using MICRO-CT
Christoph H. Arns, Adrian Sheppard, Dietmar W. Hutmacher et al. · Biomaterials · 2007 · 427 citations