Manganese-Catalyzed Carbonylation of Unactivated Alkyl Bromides with Alkylidenecyclopropanes

Abstract

The transition-metal-catalyzed carbonylation reaction has emerged as a powerful method for the construction of carbonyl compounds. However, very few examples have worked for the carbonylative coupling of organic halides with alkenes. We report herein the Mn-catalyzed carbonylation of unactivated alkyl bromides with alkylidenecyclopropanes. It represents the rare progress on the Mn-catalyzed carbonylation of alkyl bromides with a carbon nucleophile. A broad range of primary and secondary alkyl bromides reacted smoothly with ACPs to afford 1,2-dihydronaphthalene derivatives in good yields. The broad applicability of this protocol was further highlighted by the late-stage modification of several natural products and pharmaceuticals.