SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIVITY OF COMPLEXES OF 2-CARBONYLPROPIONYL (PYRIDINE-4-FORMYL) HYDRAZONE WITH RARE EARTHS

Abstract

2-Carbonylpropionyl (pyridine-4-formyl) hydrazone (H2PPPH)has been synthesized by a simple method. It is a weak acid, and the complexation was carried out in the water solution of rare earth carbonates. 13 complexes have general composition of RE2(PPFH)3·nH2O (RE=La～Yb, n=2～3). The structures and properties of the complexes were characterized by elemental analysis, IR, UV spectra, TGA-DTA, molar conductance and 1H NMR measuramcnts. Eu2(PPFH)3·3H2O was showed to have a certain antitumor activity.