Cannabidiol mitigates radiation-induced intestine ferroptosis via facilitating the heterodimerization of RUNX3 with CBFβ thereby promoting transactivation of GPX4

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Orrin Devinsky, J. Helen Cross, Linda Laux et al. · New England Journal of Medicine · 2017 · 1.7K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Michael M. Gaschler, Alexander A. Andia, Hengrui Liu et al. · Nature Chemical Biology · 2018 · 717 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8

Microcolony Survival Assay for Cells of Mouse Intestinal Mucosa Exposed to Radiation

H. Rodney Withers, M. M. Elkind · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · 1970 · 705 citations

Medicine, Cell Biology, Radiation Biophysics +16

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

Daiha Shin, Eun Hye Kim, Jaewang Lee et al. · Free Radical Biology and Medicine · 2018 · 536 citations

Medicine, Oncology, Pharmacology +12

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

Yue Wang, Lixin Zheng, Wenjing Shang et al. · Cell Death and Differentiation · 2022 · 409 citations · Full text

Life Sciences, Cell Biology, Oncology +17