1f:T49c,Radiomics aims to quantify phenotypic characteristics on medical imaging through the use of automated algorithms. Radiomic artificial intelligence (AI) technology, either based on engineered hard-coded algorithms or deep learning methods, can be used to develop noninvasive imaging-based biomarkers. However, lack of standardized algorithm definitions and image processing severely hampers reproducibility and comparability of results. To address this issue, we developed PyRadiomics, a flexible open-source platform capable of extracting a large panel of engineered features from medical images. PyRadiomics is implemented in Python and can be used standalone or using 3D Slicer. Here, we discuss the workflow and architecture of PyRadiomics and demonstrate its application in characterizing lung lesions. Source code, documentation, and examples are publicly available at www.radiomics.io With this platform, we aim to establish a reference standard for radiomic analyses, provide a tested and maintained resource, and to grow the community of radiomic developers addressing critical needs in cancer research. Cancer Res; 77(21); e104-7. ©2017 AACR.20:T412,Five properties of texture, namely, coarseness, contrast, business, complexity, and texture strength, are given conceptual definitions in terms of spatial changes in intensity. These conceptual definitions are then approximated in computational forms. In comparison with human perceptual measurements, the computational measures have shown good correspondences in the rank ordering of ten natural textures. The extent to which the measures approximate visual perception was investigated in the form of texture similarity measurements. These results were also encouraging, although not as good as in the rank ordering of the textures. The differences may be due to the complex mechanism of human usage of multiple cues. Improved classification results were obtained using the above features as compared with two existing texture analysis techniques. The application of the features in agricultural land-use classification is considered.< >21:T601,

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