D-Limonene: Promising and Sustainable Natural Bioactive Compound

Abstract

The discovery of antibiotics and pesticides has greatly contributed to the social and economic development of human society but, due to the long-term irrational application, it has led to drug-resistant microorganisms, environmental damage, and other hazards, so the selection of alternative natural, safe, and non-hazardous bioactive substances is an effective solution for this problem. D-limonene is a bioactive compound widely present in various plant essential oils, exhibiting excellent broad-spectrum bioactivity and promising prospects for development and clinical application. This review provides a detailed overview of the biological activities of D-limonene, emphasizing its antimicrobial, anthelmintic, insecticidal, and medicinal potential. While nanoencapsulation technology shows promise in improving the physicochemical properties of D-limonene and enhancing its practical applications, it is also crucial to comprehensively evaluate the potential side effects of D-limonene before use.