Evaluation of glomerular hemodynamic changes by sodium-glucose-transporter 2 inhibition in type 2 diabetic rats using in vivo imaging

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

Vlado Perkovic, Meg Jardine, Bruce Neal et al. · New England Journal of Medicine · 2019 · 6K citations · Full text

Medicine, Nephrology, Pharmacology +17

Dapagliflozin in Patients with Chronic Kidney Disease

Hiddo J.L. Heerspink, Bergur V. Stefánsson, Ricardo Correa‐Rotter et al. · New England Journal of Medicine · 2020 · 5.2K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Stefanie Dimmeler, Ingrid Fleming, Beate Fißlthaler et al. · Nature · 1999 · 3.6K citations

Life Sciences, Biochemistry, Molecular Biology +15

Insulin-stimulated Activation of eNOS Is Independent of Ca2+ but Requires Phosphorylation by Akt at Ser1179

Monica Montagnani, Hui Chen, Valarie A. Barr et al. · Journal of Biological Chemistry · 2001 · 540 citations · Full text

Life Sciences, Cell Biology, Physiology +15

The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial

Erik J.M. van Bommel, Marcel H.A. Muskiet, Michaël J.B. van Baar et al. · Kidney International · 2019 · 341 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16