Functional genomic analysis of the isolated potential probiotic <i>Lactobacillus delbrueckii</i> subsp. <i>indicus</i> TY-11 and its comparison with other <i>Lactobacillus delbrueckii</i> strains

Abstract

This study aimed to conduct functional genomic analysis to uncover the probiotic potential of <i>Lactobacillus delbrueckii</i> subsp. <i>indicus</i> TY-11 isolated from native yogurt in Bangladesh. We also performed transmission electron microscopic (TEM) analysis, comparative genomic study as well as phylogenetic tree construction with 332 core genes from 262 genomes. In our current investigation, we revealed a number of common and unique excellences of the probiotic <i>Lactobacillus delbrueckii</i> subsp. <i>indicus</i> TY-11 that are likely to be important to illustrate its intestinal residence and probiotic roles. This is the first study to explore the molecular insights into intestinal residence and probiotic roles, including antimicrobial activities and antibiotic sensitivity, of a representative strain (TY-11) of <i>Lactobacillus delbrueckii</i> subsp. <i>indicus</i>.