Concepedia

Adeno-associated virus perfusion enhanced expression: A commercially scalable, high titer, high quality producer cell line process

Wei Xue, Cameron Fulco, Sha Sha, Nick A. Alden, Jan Panteli, Patrick Hossler, James A. Warren

Molecular Therapy — Methods & Clinical Development · 2024 · 13 citations · 20 references

DOIFull text

Open access

Concepts

Abstract

GC/mL. The APEX production platform marks a significant leap forward in the efficient and effective manufacturing of rAAV vector products.

References

20

Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus

Xiao Xiao, Juan Li, R. Jude Samulski · Journal of Virology · 1998 · 1.4K citations · Full text

, , +10

Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner

Reika Shiratori, Kenta Furuichi, Masashi Yamaguchi et al. · Scientific Reports · 2019 · 287 citations · Full text

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Cell Lines for the Production of Recombinant Adeno-Associated Virus

K. Reed Clark, Frosso Voulgaropoulou, David M. Fraley et al. · Human Gene Therapy · 1995 · 253 citations

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Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process

Marie‐Françoise Clincke, Carin Mölleryd, Ye Zhang et al. · Biotechnology Progress · 2013 · 237 citations · Full text

, , +17

Spontaneous decomposition of glutamine in cell culture media

George L. Tritsch, Ginny Moore · Experimental Cell Research · 1962 · 199 citations

, , +10