Non-vascular ATP-sensitive potassium channel activation does not trigger migraine attacks: A randomized clinical trial

Abstract

The lack of migraine induction upon activation of the Kir6.2/SUR1 channel subtype suggests it may not contribute to migraine pathogenesis. Our findings point to K_ATP channel blockers that target the Kir6.1/SUR2B subtype, found in cerebral vasculature, as potential candidates for innovative antimigraine treatments.<b>Registration number:</b> NCT04744129.