A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

PubMed · 1997 · 66.5K citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Analytical Biochemistry · 1987 · 63.2K citations

Nucleic Acid Chemistry, Engineering, Natural Sciences +7

A new technique for the assay of infectivity of human adenovirus 5 DNA

Frank L. Graham, A.J. van der Eb · Virology · 1973 · 9.7K citations

Diagnostic Virology, Viral Diagnostics, Natural Sciences +6

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

Ralf Schreck, P. Rieber, Patrick A. Baeuerle · The EMBO Journal · 1991 · 3.8K citations · Full text

Inflammation, Cytokine, Transcriptional Regulation +13

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

Ole Thastrup, Peter J. Cullen, Bjørn K. Drøbak et al. · Proceedings of the National Academy of Sciences · 1990 · 3.3K citations · Full text

Ca2+ Homeostasis, Intracellular Ca2+ Stores, Cytoskeleton +19