Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycaemia

Abstract

EC-enriched aquaporins regulate the diameter of blood vessels through an intracellular vacuole-mediated process under hyperglycaemic conditions. These findings collectively suggest that aquaporins expressed in ECs hold significant promise as potential targets for gene therapy aimed at addressing vascular perfusion defects associated with diabetes.