LDL-C and TC Mediate the Risk of PNPLA3 Inhibition in Cardiovascular Diseases

Abstract

This study suggests that PNPLA3 inhibition increases the risk of major CVDs. Moreover, blood LDL-C and TC may mediate a significant proportion of the associations between PNPLA3 inhibition and coronary atherosclerosis, coronary heart disease, or myocardial infarction.