Why Perfluorocarbon nanoparticles encounter bottlenecks in clinical translation despite promising oxygen carriers?

Survival of Mammals Breathing Organic Liquids Equilibrated with Oxygen at Atmospheric Pressure

Leland C. Clark, Frank Gollan · Science · 1966 · 789 citations

Life Sciences, Physiology, Zoology +14

Solubility and transport phenomena in perfluorochemicals relevant to blood substitution and other biomedical applications

Jean G. Riess, Maurice Blanc · Pure and Applied Chemistry · 1982 · 284 citations · Full text

Engineering, Pharmacokinetics, Bioavailability +9

Perfluorohexane‐Encapsulated Mesoporous Silica Nanocapsules as Enhancement Agents for Highly Efficient High Intensity Focused Ultrasound (HIFU)

Xia Wang, Hangrong Chen, Yu Chen et al. · Advanced Materials · 2012 · 239 citations

Pharmacy, Biomedical Engineering, Pharmaceutics +17

Clinical Studies of A Perfluorochemical Whole Blood Substitute (Fluosol-DA)

Takao MITSUNO, Harumasa Ohyanagi, R Naito · Annals of Surgery · 1982 · 221 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +6

United Kingdom National Ophthalmology Database Study of Vitreoretinal Surgery: Report 2, Macular Hole

Timothy L. Jackson, Paul H. J. Donachie, J M Sparrow et al. · Ophthalmology · 2012 · 171 citations

Medicine, Ophthalmology, Surgery +11