Peripheral HMGB1 is linked to O₃ pathology of disease‐associated astrocytes and amyloid

Abstract

Astrocytes are part of the lung-brain axis, regulating how air pollution affects plaque pathology. Ozone (O₃) astrocyte effects are associated with increased plaques and modified by plaque localization. O₃ uniquely disrupts the astrocyte transcriptomic and proteomic disease-associated astrocyte (DAA) phenotype in plaque associated astrocytes (PAA). O₃ changes the PAA cell contact with microglia and cell-cell communication gene expression. Peripheral myeloid cell high mobility group box 1 regulates O₃-induced transcriptomic changes in the DAA phenotype.