Concepedia

Photocatalytic organosulfur reagent-promoted selective mono-(deutero)hydrodechlorination

Junlei Wang, Guocheng Gao, Jiadong Cheng, Jintao Li, Xue‐Mei Chen, Daohai Zhang, Hongqing Li, Xiaohua Cai, Binbin Huang

Green Chemistry · 2024 · 17 citations · 51 references

DOI

Concepts

Abstract

Selective partial C–Cl bond reduction represents an important strategy for the construction of valuable chlorine-containing skeletons.

References

51

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition‐Metal Complexes

Eric M. Simmons, John F. Hartwig · Angewandte Chemie International Edition · 2012 · 2.1K citations

, , +14

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

Thomas G. Gant · Journal of Medicinal Chemistry · 2013 · 758 citations

, , +13

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

Yong Yao Loh, Kazunori Nagao, Andrew J. Hoover et al. · Science · 2017 · 571 citations

, , +15

First deuterated drug approved

Charles W. Schmidt · Nature Biotechnology · 2017 · 456 citations

, , +1

Photocatalytic activation of alkyl chlorides by assembly-promoted single electron transfer in microheterogeneous solutions

Maciej Giedyk, Rok Narobe, Sophia Weiß et al. · Nature Catalysis · 2019 · 212 citations

, , +17