Prognostic and functional importance of both overt and subclinical left ventricular systolic dysfunction in systemic sclerosis

Abstract

Both overt and subclinical SSc-associated LV dysfunction are associated with worse survival and impaired physical function. The frequency of abnormal LV-GLS in those with consistently normal LVEF suggests an under-appreciated burden of subtle LV systolic dysfunction in SSc that has a significant impact on patient symptomatology.