A solvent-free mechanochemical electrophilic C–H thiocyanation of indoles and imidazo[1,2- <i>a</i> ]pyridines using a cost-effective combination of <i>N</i> -chlorosuccinimide-NaSCN and tandem C–C and C–S bond formation

Abstract

Herein, we demonstrate a solvent-free and cost-effective mechanochemical electrophilic thiocyanation of indoles and imidazo[1,2- a ]pyridines and tandem double C–H activation leading to the formation of C-2 aryl and C-3 thiocyano indoles in a mixer-mill.