Integrated Copper Nanomaterials‐Decorated Microsphere Photothermal Platform for Comprehensive Melanoma Treatment

Abstract

Patients who undergo resection for melanoma face challenges, such as delayed healing and radiation dermatitis. Moreover, incomplete tumor resection is a key factor contributing to poor prognosis and increased recurrence rates. However, a therapeutic platform that can effectively prevent tumor recurrence and promote wound healing remains a challenge. Hence, a pioneering approach is presented using melanoma‐derived cancer cell membrane (CM) as a tumor antigen to encapsulate copper (Cu)‐based metal‐organic framework (MOF) nanomaterials to fabricate nanomaterials termed MOF@CM. Then MOF@CM is adsorbed onto polydopamine (PDA)‐modified poly lactic‐co‐glycolic acid (PLGA) porous microspheres (PLGA/PDA) to develop the copper nanomaterials‐decorated microspheres termed PLGA/PDA‐CCM (PLGA/PDA loaded with CM‐coated MOF). It exerts homologous tumor targeting and photothermal effects, inducing immunogenic cell death. Simultaneously, the sustained release of MOF@CM shows enhanced antigen presentation in dendritic cells (DCs) with the help of CpG, and induces DC maturation and activated immune responses, acting as an effective vaccine to prevent tumor recurrence. The platform harnesses the combined advantages of the local thermal effect and the presence of a Cu‐based MOF, which endow antibacterial properties and stimulate angiogenesis, thereby facilitating wound healing and mitigating radiation dermatitis. This integrated microsphere treatment platform represents a promising strategy for addressing melanoma.