Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility

Abstract

Our study registers a day-night rhythm in chromatin accessibility that accompanies diurnal cycles in ventricular myocytes. Our approaches directly implicate the cardiac GR in the myocyte excitability rhythm and mechanistically link the ZT12 surge in glucocorticoids to intrinsic VA propensity at this time.