Concepedia

Discovery of novel benzimidazole derivatives as potent HDACs inhibitors against leukemia with (Thio)Hydantoin as zinc-binding moiety: Design, synthesis, enzyme inhibition, and cellular mechanistic study

Hanan Gaber Abdulwahab, Reda El‐Sayed Mansour, Thoraya A. Farghaly, Hend M. El‐Sehrawi

Bioorganic Chemistry · 2024 · 13 citations · 19 references

DOI

Concepts

References

19

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

Antoine Daina, Olivier Michielin, Vincent Zoete · Scientific Reports · 2017 · 17.1K citations · Full text

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FDA Approval Summary: Vorinostat for Treatment of Advanced Primary Cutaneous T-Cell Lymphoma

Bhupinder Mann, John R. Johnson, Martin H. Cohen et al. · The Oncologist · 2007 · 1.4K citations · Full text

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Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

Yang Hai, David W. Christianson · Nature Chemical Biology · 2016 · 487 citations · Full text

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Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells

Sean C. Dowdy, Shujuan Jiang, Xuanting Zhou et al. · Molecular Cancer Therapeutics · 2006 · 140 citations

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Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity

Huda K. Mahmoud, Thoraya A. Farghaly, Hanan Gaber Abdulwahab et al. · European Journal of Medicinal Chemistry · 2020 · 79 citations · Full text

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