Microdialysis coupled with droplet microfluidics and mass spectrometry for determination of neurotransmitters <i>in vivo</i> with high temporal resolution

Abstract

Samples collected from brain of living subjects are segmented to nanoliter droplets and infused to the mass spectrometer. Temporal resolution for in vivo concentration dynamics of key neurotransmitters of 10 s is achieved. Created with Biorender.com.