Sex differences in single neuron function and proteomics profiles examined by patch‐clamp and mass spectrometry in the locus coeruleus of the adult mouse

Abstract

Male LC noradrenergic neurons exhibit higher intrinsic excitability compared to those from females. The discernible sex-based differences in excitability could be ascribed to varying protein expression profiles, especially within pathways that regulate protein synthesis and degradation. This study lays the groundwork for future studies focusing on the interplay between proteomics and neuronal function examined in individual cells.