Transdermal delivery of IBU-PLGA nanoparticles with dissolving microneedle array patch

Abstract

There are few systematic studies using microneedles to deliver ibuprofen through the skin. In this study, Ibuprofen was encapsulated in poly (lactide-co-Glycolide) (PLGA) network to form nanoparticles(IBU-NPs), then the IBU-NPs were mixed with Sodium Hyaluronate to fabricate dissolving microneedles array patch (MNP) and applied in mice model to observe its effect. In mouse model, IBU-NPs microneedles could effectively deliver ibuprofen to mice and significantly reduced the number of writhe, significantly reduced the mRNA of CGRP, COX-2, TNF–α, IL-1β, IL-6 and increased the mRNA of opioid receptor. This study introduces a rapid microneedle transdermal delivery technique for ibuprofen nanoparticles and confirms its effectiveness in terms of the mechanism of action.