TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells - Concepedia

Concepedia

Publication | Open Access

TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells

DOI Full Paper Access

20

Citations

56

References

2024

Year

Beatrice Claudia Cianciotti, Zulma Magnani, Alessia Ugolini, Barbara Camisa, Ivan Merelli, Valentina Vavassori, Alessia Potenza, Antonio Imparato, Francesco Manfredi, Danilo Abbati,

Frontiers in Immunology

Abstract

These results highlight that TIM-3, LAG-3, and 2B4 disruptions increase the therapeutic benefit of tumor specific cellular products and suggest distinct, non-redundant roles for IRs in anti-tumor responses.

References

	Year	Citations

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