Activating astrocytic α2A adrenoceptors in hippocampus reduces glutamate toxicity to attenuate sepsis-associated encephalopathy in mice

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A. Liddelow, Kevin A. Guttenplan, Laura Clarke et al. · Nature · 2017 · 8K citations · Full text

Medicine, Neurobiology, Neuroscience +14

Immunodesign of experimental sepsis by cecal ligation and puncture

Daniel Rittirsch, Markus Huber‐Lang, Michael A. Flierl et al. · Nature Protocols · 2008 · 2.2K citations · Full text

Veterinary Medicine, Immunology, Pathobiology +12

Localization of neuronal and glial glutamate transporters

Jeffrey D. Rothstein, Lee J. Martin, Allan I. Levey et al. · Neuron · 1994 · 1.7K citations

Life Sciences, Neurobiology, Neuroscience +13

α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex

Min Wang, Brian P. Ramos, Constantinos D. Paspalas et al. · Cell · 2007 · 674 citations · Full text

Life Sciences, Neuroscience, Pharmacology +15

Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial

Pratik P. Pandharipande, Robert D. Sanders, Timothy D. Girard et al. · Critical Care · 2010 · 418 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +12