Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots—A new collection method for remote settings

Abstract

A wide array of biomarkers related to Alzheimer's disease (AD) and neurodegeneration were detectable in dried plasma spots (DPS^venous). DPS^venous biomarkers correlated with standard procedures and cognitive status. DPS^venous biomarkers had a good diagnostic accuracy discriminating amyloid status. Our findings show the potential interchangeability of DPS^venous and plasma sampling. DPS^venous may facilitate remote and temperature-independent sampling for AD biomarker measurement. Innovative tools for blood biomarker sampling may help recognizing the earliest changes of AD.