Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

Jedd D. Wolchok, Vanna Chiarion‐Sileni, René González et al. · New England Journal of Medicine · 2017 · 5.4K citations · Full text

Pharmacy, Oncology, Pharmacotherapy +17

Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production.

John P. Leonard, Matthew L. Sherman, Gerald L. Fisher et al. · PubMed · 1997 · 814 citations

Pharmacy, Immunology, Toxicology +16

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

Ryosuke Kojima, Daniel Bojar, Giorgio Rizzi et al. · Nature Communications · 2018 · 736 citations · Full text

Pharmacy, Biotechnology, Neuroscience +15

Nonviral delivery of self-amplifying RNA vaccines

Andrew J. Geall, Ayush Verma, Gillis R. Otten et al. · Proceedings of the National Academy of Sciences · 2012 · 667 citations · Full text

Life Sciences, Biotechnology, Immunology +17

Efficient RNA drug delivery using red blood cell extracellular vesicles

Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok et al. · Nature Communications · 2018 · 644 citations · Full text

Pharmacy, Biotechnology, Pharmaceutics +17