Single-cell sequencing reveals an important role of SPP1 and microglial activation in age-related macular degeneration

Abstract

Our findings indicated that SPP1 and microglial activation might play an important role in the pathophysiology of AMD. Therefore, SPP1 might serve as a potential therapeutic target for AMD. More <i>in vitro</i> and <i>in vivo</i> studies are required to confirm the results and the therapeutic effect of SPP1-targeting strategy.