Membrane properties modulation by SanA: implications for xenobiotic resistance in Salmonella Typhimurium

Abstract

Our findings demonstrated that the absence of <i>sanA</i> increased membrane permeability, hydrophilicity, and positive charge, resulting in enhanced resistance to certain antibiotics that target peptidoglycan synthesis. Furthermore, the <i>sanA</i> deletion mutant demonstrated enhanced replication rates within primary macrophages, highlighting its ability to evade the bactericidal effects of the immune system. Taking together, we provide valuable insights into a poorly known SanA protein, highlighting the complex interplay among bacterial genetics, membrane physiology, and antibiotic resistance, underscoring its significance in understanding <i>Salmonella</i> pathogenicity.