Research progress of 3D-bioprinted functional pancreas and in vitro tumor models

Abstract

With the rapid development of three-dimensional (3D) bioprinting technology, the research revolving around in vitro functional pancreas and tumor models has become the focus of attention in the field of life sciences. This review aims to summarize and deeply discuss the research progress and prospects of 3D-bioprinted functional pancreas and in vitro tumor models. The efforts in improving 3D printing technology to increase its accuracy and reliability in the biomedical applications have been ramped up over the past few years. Researchers are now able to create highly complex 3D structures through precise layering of biological materials at the micron scale. For instance, a functional pancreas can be printed in vitro by combining cells, biomaterials, and growth factors. The introduction of new technologies allows researchers to more accurately simulate the growth and spread of tumors, providing a more realistic platform for cancer treatment research. This not only helps accelerate the process of drug screening, but also lays the foundation for personalized medicine. As multiple disciplines, such as materials science, cell biology, and engineering, continue to converge with 3D bioprinting, emergence of more innovative applications is anticipated. However, despite significant progress, many technical and ethical challenges still need to be overcome before practical clinical applications can be implemented. In summary, the application of bioprinting technology is of great significance to the study of functional pancreas and in vitro tumor models, which could lead to new breakthroughs in the development of clinical treatment and personalized medicine.