Journal of Applied Physiology · 2023 · 10 citations · 23 references
Life SciencesBiochemistryCell BiologyCellular MetabolismMetabolismMitochondrial BiologyMitochondrial BiochemistryMitochondrial BioenergeticsMitochondrial DysfunctionMitochondrial MetabolismMitochondrial PhysiologyMitophagyMitochondrial Adaptations To ExerciseMitochondrial Biogenesis In MuscleMitochondrial Dna (Mtdna) MaintenanceMuscle Oxidative CapacitySkeletal Muscle BioenergeticsSkeletal Muscle PhysiologyTherapeutic Target Identification
Our understanding of the role of transcription factor E3 (TFE3) in skeletal muscle is very limited. This research shows that TFE3 plays a direct role in skeletal muscle mitochondrial enhancement with exercise training, thereby introducing a paradigm shift in our perception of the function of TFE3 in mitochondrial maintenance, beyond mitophagy. This research serves to introduce TFE3 as a protein that holds promise as a future therapeutic target for metabolic diseases and skeletal muscle dysfunction.
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A Gene Network Regulating Lysosomal Biogenesis and Function
Marco Sardiello, Michela Palmieri, Alberto di Ronza et al. · Science · 2009 · 2.5K citations