Concepedia

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy

Yuhong Ma, Wei Wang, Mujiao He, Yunzhu Liu, Caihua Li, Yinan Zhong, Quanmin Bu, Dechun Huang, Hongliang Qian, Wei Chen

Biomaterials Science · 2023 · 13 citations · 37 references

DOI

Concepts

Abstract

results showed that MNs@GI effectively regulated glycemic levels within the normal range for approximately 10 h compared to that of only insulin-loaded microneedles (MNs@INS). Consequently, the highly insulin-loaded, multi-responsive, and pH-triggered MN system has tremendous potential for diabetes treatment.

References

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