Handelin alleviates cachexia‐ and aging‐induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation

Abstract

Handelin ameliorated cachexia- and aging-induced skeletal muscle atrophy in vitro and in vivo, by maintaining homeostasis of protein synthesis and degradation, possibly by inhibiting inflammation. Handelin is a potentially promising drug candidate for the treatment of muscle wasting.