Exhaled nitric oxide, eosinophils and current smoking in COPD patients

Abstract

There is increasing interest in type 2 (T2) inflammation in COPD [1]. COPD patients with higher blood eosinophil counts (BECs) have a greater T2 profile, including IL-13 expression, in bronchial brush and sputum samples [2–4]. IL-13 upregulates inducible nitric oxide synthase, increasing fractional exhaled nitric oxide (FeNO) levels. Footnotes This manuscript has recently been accepted for publication in the ERJ Open Research . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.